ABSTRACT
Introduction: Some patients with comorbidity such as diabetes are at risk of worsening after being infected with the COVID-19 and they usually adjust their diet during the recovery process. Aim: To explore the use of Stevia rebaudiana leaves as a natural sweetener recommended for COVID-19 patients and the nanoparticle approach of S. rebaudiana extract to improve the efficacy. Methods: Four electronic databases (Google Scholar, PubMed, Scopus, and ScienceDirect) were used with specified inclusion and exclusion criteria set. Results: The glycosides produced by S. rebaudiana are 300 times sweeter than sucrose, low in calories, and can control blood sugar levels and increase insulin secretion. The application of nanoparticles in S. rebaudiana extract is a new step to maximise efficacy, increase stability and solubility. Conclusion: S. rebaudiana can be used as an alternative diet for COVID-19 diabetes patients. The application of the nanoparticles can increase the stability and solubility, thus improving the efficacy.